肝素纳米粒的研究进展

赵娜,崔慧斐

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (18) : 1531-1535.

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中国药学杂志 ›› 2013, Vol. 48 ›› Issue (18) : 1531-1535. DOI: 10.11669/cpj.2013.18.004
综述

肝素纳米粒的研究进展

  • 赵娜12,崔慧斐12
作者信息 +

Advance of Heparin-Coated and Heparin-Based Nanoparticles

  • ZHAO Na1,2, CUI Hui-fei1,2
Author information +
文章历史 +

摘要

目的综述肝素纳米粒的研究进展。方法检索并阅读近年来国内外文献,按照结构、合成方法、性质及应用前景四方面进行综述。结果目前研究较多的是经肝素表面修饰的纳米粒以及以肝素及其衍生物为骨架的纳米粒,前者有助于提高纳米粒的生物相容性、靶向性和载药量,后者主要用于蛋白质和抗肿瘤药物的靶向运输。结论纳米粒与肝素的结合,将为肝素的临床应用开辟新的可能,同时也能提高现有的治疗用纳米粒的生物性能。但在走向临床应用前还要解决制备工艺、药理学及毒理学评价、质量控制等问题。

Abstract

OBJECTIVE To summarize advances in heparin nanoparticles. METHODS Literatures recently published were searched and reviewed for the structures, synthetic methods, properties and application prospects of heparin nanoparticle. RESULTS Nowadays, researches are focused on heparin-conjugated nanoparticles and nanoparticles assembled by heparin or heparin derivatives. The former can improve biocompatibility, targeting ability and drug loading capacity, while the latter were utilized in targeting transportation of protein and antitumor drugs. CONCLUSION The combination of nanoparticles and heparin may bring new possibilities for clinical applications of heparin and improve the biological capabilities of existing medicinal nanoparticles. However, a great deal of problems, such as preparation process, pharmacology and toxicology evaluation, and quality control should be resolved first.

关键词

载药纳米粒 / 肝素 / 表面修饰 / 运载蛋白质 / 运载抗肿瘤药物

Key words

nanoparticle / heparin / surface modification / protein delivery / antitumor drug delivery

引用本文

导出引用
赵娜,崔慧斐. 肝素纳米粒的研究进展[J]. 中国药学杂志, 2013, 48(18): 1531-1535 https://doi.org/10.11669/cpj.2013.18.004
ZHAO Na,, CUI Hui-fei,. Advance of Heparin-Coated and Heparin-Based Nanoparticles[J]. Chinese Pharmaceutical Journal, 2013, 48(18): 1531-1535 https://doi.org/10.11669/cpj.2013.18.004
中图分类号: R943   

参考文献

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